The Importance Of Protein Degradation - 783 Words

The authors’ goal in conducting this experiment was to establish a link between, among other things, protein degradation through the ubiquitin-protease system (UPS) and the consolidation and reconsolidation of long-term fear memories. This research was necessary because, while research had been done linking protein degradation to synaptic plasticity, no study had been performed to analyze the role of UPS in the amygdala, where long-term fear memories are believed to be stored. Additionally, prior research had led to conflicting reports of the importance of protein degradation in consolidation as opposed to reconsolidation, which the authors intended to clarify. To obtain the desired information, researchers tested male Long Evans rats’†¦show more content†¦Most research findings confirmed what prior research indicated – protein degradation and synthesis are essential in memory formation and memory formation relies on NMDA. However, the research indicated differences between the memory processes used by the hippocampus and amygdala in that prior researchers had found little evidence that protein degradation was a necessary part of the consolidation of memories in hippocampus. This led researchers to conclude that the amygdala and hippocampus may be more similar with regard to reconsolidation of memories than consolidation of memories. Analysis: Prior to reading the article, I had very little understanding of the importance of proteins in memory functions. I believed them to be most important with regard to enzymatic functioning and structural composition. However, the article indicates how incredibly important the minutiae of protein function are to a properly functioning memory. Based on protein function, researchers were able to control if and how much the rats were able to remember. The data do seem to support the authors’ conclusions. Protein degradation was measured by the presence of ubiquitin, which was a fairly accurate measurement tool. In addition, the researchers used an abundance of controlled groups in order to isolate the desired variable – the combination of shock and auditory cue. Conclusions about the presence of elevated protein degradation are supported by the collected data from theShow MoreRelatedMechanisms for mRNA Degradation1349 Words   |  5 PagesMessenger RNA (mRNA) is extremely i mportant in expression of protein-coding genes. mRNA molecules contain the genetic code for synthesis of particular polypeptides during translation. (Lewin’s Genes XI, 624) Messenger RNAs are unstable molecules due to the fact that cells have ribonucleases. These ribonucleases can specifically target mRNA molecules in the cytoplasm. There are two types of ribonucleases. 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